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1

Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice

Yuusuke Akao, Takashi Ebihara, Hisayo Masuda, Yoshiko Saeki, Takashi Akazawa, Kaoru Hazeki, Osamu Hazeki, Misako Matsumoto, Tsukasa Seya

Journal:

Year:

2009

Language:

english

File:

PDF, 1.25 MB

english, 2009

2

Relationship between time-resolved and non-time-resolved Beer - Lambert law in turbid media

Nomura, Yasutomo, Hazeki, Osamu, Tamura, Mamoru

Journal:

Physics in Medicine and Biology

Year:

1997

Language:

english

File:

PDF, 187 KB

english, 1997

3

Role of Syk in Fcγ receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C

Kaoru Hazeki, Osamu Hazeki, Tsuyoshi Matsuo, Tsukasa Seya, Toshiyuki Yamashita, Shigeharu Nagasawa, Hamid Band, Michio Ui

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 240 KB

english, 1999

4

Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways

Kaoru Hazeki, Naoyo Masuda, Kenji Funami, Naoe Sukenobu, Misako Matsumoto, Shizuo Akira, Kiyoshi Takeda, Tsukasa Seya, Osamu Hazeki

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

5

Comparison of the protein profiles between the achilles and patella tendon in rats

Yoshimasa Ishii, Masataka Deie, Nobuo Adachi, Osamu Hazeki, Naoki Okamura, Patrick Sharman, Yuji Yasunaga, Mitsuo Ochi

Journal:

Materials Science and Engineering: C

Year:

2008

Language:

english

File:

PDF, 547 KB

english, 2008

6

Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines

Tetsuo Ito, Noboru Maki, Osamu Hazeki, Kazuki Sasaki, Munenori Nekooki

Journal:

Cell Biology International

Year:

2007

Language:

english

File:

PDF, 289 KB

english, 2007

7

Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors

Toshiaki Katada, Hiroshi Kurosu, Taro Okada, Takahiro Suzuki, Noriko Tsujimoto, Shunsuke Takasuga, Kenji Kontani, Osamu Hazeki, Michio Ui

Journal:

Chemistry and Physics of Lipids

Year:

1999

Language:

english

File:

PDF, 478 KB

english, 1999

8

cAMP Stimulates Human Immunodeficiency Virus (HIV-1)from Latently Infected Cells of Monocyte-Macrophage Lineage: Synergism with TNF-α

Md.Iqbal Hossain Chowdhury, Yoshio Koyanagi, Sankichi Horiuchi, Osamu Hazeki, Michio Ui, Kiyoshi Kitano, David W. Golde, Kenzo Takada, Naoki Yamamoto

Journal:

Year:

1993

File:

PDF, 372 KB

1993

9

Pertussis Toxin Inhibits Induction of Human Immunodeficiency Virus Type 1 in Infected Monocytes

Iqbal Hossain Chowdhury, Yoshio Koyanagi, Osamu Hazeki, Michio Ui, Naoki Yamamoto

Journal:

Year:

1994

File:

PDF, 398 KB

1994

10

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Michio Ui, Taro Okada, Kaoru Hazeki, Osamu Hazeki

Journal:

Trends in Biochemical Sciences

Year:

1995

Language:

english

File:

PDF, 643 KB

english, 1995

11

Shikonin Stimulates Glucose Uptake in 3T3-L1 Adipocytes via an Insulin-Independent Tyrosine Kinase Pathway

Reiko Kamei, Yoshinori Kitagawa, Michinori Kadokura, Fumiyuki Hattori, Osamu Hazeki, Yousuke Ebina, Tatsuro Nishihara, Shinzo Oikawa

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

12

Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fcγ receptor signaling

Tsuyoshi Matsuo, Kaoru Hazeki, Osamu Hazeki, Toshiaki Katada, Michio Ui

Journal:

Year:

1996

Language:

english

File:

PDF, 563 KB

english, 1996

13

Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events

Osamu Hazeki, Kaoru Hazeki, Toshiaki Katada, Michio Ui

Journal:

Journal of Lipid Mediators and Cell Signalling

Year:

1996

Language:

english

File:

PDF, 132 KB

english, 1996

14

Inhibition of PTEN and activation of Akt by menadione

Kyoko Yoshikawa, Kiyomi Nigorikawa, Mariko Tsukamoto, Namiko Tamura, Kaoru Hazeki, Osamu Hazeki

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 650 KB

english, 2007

15

Inhibition of lipid A-mediated type I interferon induction by Bactericidal/permeability-increasing protein (BPI)

Masahiro Azuma, Aya Matsuo, Yukari Fujimoto, Koichi Fukase, Kaoru Hazeki, Osamu Hazeki, Misako Matsumoto, Tsukasa Seya

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 357 KB

english, 2007

16

Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling

Miho Kubo-Murai, Kaoru Hazeki, Naoe Sukenobu, Kyoko Yoshikawa, Kiyomi Nigorikawa, Kazumi Inoue, Toshiyoshi Yamamoto, Misako Matsumoto, Tsukasa Seya, Norimitsu Inoue, Osamu Hazeki

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 721 KB

english, 2007

17

Association of phosphatidylinositol 3-kinase with the photo-oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP-1 cells

Tsuyoshi Matsuo, Kaoru Hazeki, Noriko Tsujimoto, Shin-ichi Inoue, Hiroshi Kurosu, Kenji Kontani, Osamu Hazeki, Michio Ui, Toshiaki Katada

Journal:

Year:

1996

Language:

english

File:

PDF, 411 KB

english, 1996

18

2′-benzyloxychalcone derivatives stimulate glucose uptake in 3T3-L1 adipocytes

Reiko Kamei, Michinori Kadokura, Yoshinori Kitagawa, Osamu Hazeki, Shinzo Oikawa

Journal:

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

19

Age-related changes in manganese superoxide dismutase activity in the cerebral cortex of senescence-accelerated prone and resistant mouse

Tomonori Kurokawa, Shinji Asada, Shinobu Nishitani, Osamu Hazeki

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 125 KB

english, 2001

20

Developmentally retarded expression of the glial glutamate transporter, GLT-1, in the cerebral cortex of senescence-accelerated prone mouse SAMP8

Tomonori Kurokawa, Saori Suzuki, Kohji Nagaoka, Osamu Hazeki

Journal:

International Congress Series

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

21

Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3

Hazeki Kaoru, Seya Tsukasa, Hazeki Osamu, Ui Michio

Journal:

Molecular Immunology

Year:

1994

Language:

english

File:

PDF, 998 KB

english, 1994

22

Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics

Kaoru Hazeki, Kiyomi Nigorikawa, Yuki Takaba, Tomohiro Segawa, Akiko Nukuda, Ayaka Masuda, Yuki Ishikawa, Koji Kubota, Shunsuke Takasuga, Osamu Hazeki

Journal:

Year:

2012

Language:

english

File:

PDF, 835 KB

english, 2012

23

Redox behavior of cytochrome C oxidase in neonatal brain

Yoko Hoshi, Osamu Hazeki, Takeshi Kida, Yoshinori Matsumoto, Mamoru Tamura

Journal:

Pediatric Neurology

Year:

1994

Language:

english

File:

PDF, 246 KB

english, 1994

24

Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20

Segawa, Tomohiro, Hazeki, Kaoru, Nigorikawa, Kiyomi, Morioka, Shin, Guo, Ying, Takasuga, Shunsuke, Asanuma, Ken, Hazeki, Osamu

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.44 MB

english, 2014

25

Ellagitannins from Lagerstroemia speciosa as Activators of Glucose Transport in Fat Cells

Hayashi, Takeo, Maruyama, Haruko, Kasai, Royji, Hattori, Katsuji, Takasuga, Shunsuke, Hazeki, Osamu, Yamasaki, Kazuo, Tanaka, Takashi

Journal:

Year:

2002

Language:

english

File:

PDF, 93 KB

english, 2002

26

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte‒macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

KODAMA, Takeshi, HAZEKI, Kaoru, HAZEKI, Osamu, OKADA, Taro, UI, Michio

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 226 KB

english, 1999

27

Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt

Kubo, Hiroshi, Hazeki, Kaoru, Takasuga, Shunsuke, Hazeki, Osamu

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 611 KB

english, 2005

28

Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages

Tamura, Namiko, Hazeki, Kaoru, Okazaki, Natsumi, Kametani, Yukiko, Murakami, Hiroki, Takaba, Yuki, Ishikawa, Yuki, Nigorikawa, Kiyomi, Hazeki, Osamu

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 843 KB

english, 2009

29

Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells

MATSUO, Tsuyoshi, HAZEKI, Kaoru, HAZEKI, Osamu, KATADA, Toshiaki, UI, Michio

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 470 KB

english, 1996

30

Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and βγ-subunits of GTP-binding proteins

OKADA, Taro, HAZEKI, Osamu, UI, Michio, KATADA, Toshiaki

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 560 KB

english, 1996

31

Focal adhesion kinase (p125 FAK ) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts

SASAKI, Takehiko, HAZEKI, Kaoru, HAZEKI, Osamu, UI, Michio, KATADA, Toshiaki

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 395 KB

english, 1996

32

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte–macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

KODAMA, Takeshi, HAZEKI, Kaoru, HAZEKI, Osamu, OKADA, Taro, UI, Michio

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 226 KB

english, 1999

33

Foreword

Journal:

Biological & Pharmaceutical Bulletin

Year:

2007

Language:

english

File:

PDF, 32 KB

english, 2007

34

Role of Phosphoinositide 3-Kinase in Innate Immunity

Hazeki, Kaoru, Nigorikawa, Kiyomi, Hazeki, Osamu

Journal:

Biological & Pharmaceutical Bulletin

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

35

17.BETA.-Hydroxy-16.ALPHA.-(125I)iodowortmannin, a Sensitive Labeling Agent for PI 3-Kinases.

HONZAWA, Shinobu, NAKADA, Masahisa, KUROSU, Hiroshi, HAZEKI, Osamu, KATADA, Toshiaki, SHIBASAKI, Masakatsu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 483 KB

1995

36

Acute effects of melatonin and its time of administration on core body temperature and heart rate in cynomolgus monkeys

Inui, Yoshitaka, Hazeki, Osamu

Journal:

The Journal of Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 795 KB

english, 2010

37

Cyclic AMP-increasing agents interfere with chemoattractant-induced respiratory burst in neutrophils as a result of the inhibition of phosphatidylinositol 3-kinase rather than receptor operated Ca2+ influx

Hazeki, Kaoru, Ahmed, Mosleh U., Hazeki, Osamu, Katada, Toshiaki, Ui, Michio

Journal:

Folia Pharmacologica Japonica

Year:

1995

File:

PDF, 4.52 MB

1995

38

NAD+-cleavage enzymes possibly involved in signal transduction

Katada, Toshiaki, Kontani, Kenji, Kukimoto, Iwao, Inoue, Shin-ichi, Hoshino, Shin-ichi, Hazeki, Osamu, Takahashi, Katsunobu, Nishina, Hiroshi

Journal:

Folia Pharmacologica Japonica

Year:

1995

File:

PDF, 4.39 MB

1995

39

Activation of Insulin Receptors by Lagerstroemin

Hattori, Katsuji, Sukenobu, Naoe, Sasaki, Tomo, Takasuga, Shunsuke, Hayashi, Takeo, Kasai, Ryoji, Yamasaki, Kazuo, Hazeki, Osamu

Journal:

Journal of Pharmacological Sciences

Year:

2003

Language:

english

File:

PDF, 228 KB

english, 2003

40

Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a

Segawa, Tomohiro, Hazeki, Kaoru, Nigorikawa, Kiyomi, Nukuda, Atsuko, Tanizawa, Tomoki, Miyamoto, Kenshiro, Morioka, Shin, Hazeki, Osamu

Journal:

Innate Immunity

Year:

2017

Language:

english

File:

PDF, 732 KB

english, 2017

41

Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages

Morioka, Shin, Nigorikawa, Kiyomi, Hazeki, Kaoru, Ohmura, Michiko, Sakamoto, Hiromi, Matsumura, Takuma, Takasuga, Shunsuke, Hazeki, Osamu

Journal:

Experimental Cell Research

Year:

2017

Language:

english

File:

PDF, 3.75 MB

english, 2017

42

Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages

Hazeki, Kaoru, Kametani, Yukiko, Murakami, Hiroki, Uehara, Masami, Ishikawa, Yuki, Nigorikawa, Kiyomi, Takasuga, Shunsuke, Sasaki, Takehiko, Seya, Tsukasa, Matsumoto, Misako, Hazeki, Osamu, Qiu, Jianm

Journal:

Year:

2011

Language:

english

File:

PDF, 654 KB

english, 2011

43

PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses

Hazeki, Kaoru, Uehara, Masami, Nigorikawa, Kiyomi, Hazeki, Osamu, Obukhov, Alexander G

Journal:

Year:

2013

Language:

english

File:

PDF, 3.89 MB

english, 2013

44

Involvement of Class II Phosphoinositide 3-Kinase α-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells

Nigorikawa, Kiyomi, Hazeki, Kaoru, Guo, Ying, Hazeki, Osamu, Gasman, Stephane

Journal:

Year:

2014

Language:

english

File:

PDF, 1.66 MB

english, 2014

45

Redox behavior of cytochrome oxidase in the rat brain measured by near-infrared spectroscopy

Hoshi, Yoko, Hazeki, Osamu, Kakihana, Yasuyuki, Tamura, Mamoru

Journal:

Journal of Applied Physiology

Year:

1997

Language:

english

File:

PDF, 141 KB

english, 1997